While I was exploring possible options to reach
Ladakh, Acute Mountain Sickness (AMS) was one thing that was cautioned in every travel forum. Mr. Google told
me that AMS is caused by low oxygen as one gains altitude; but it is not a serious issue if acclimatisation is done properly. Since Ladakh
region has many high altitude mountains (10000+ ft high), gaining such
altitudes from mean sea level within a matter of hours is not advisable. Taking
the road is by far the safest one in terms of AMS. It is advised to gain
altitude slowly, spend a night acclimatising and then resume our journey.